Early Research
Siddiqi’s early work was in plant embryology at Aligarh, and wheat genetics at the Indian Agricultural Institute in Delhi. At Glasgow University he did research for his PhD with Guido Pontecorvo on microbial genetics. He mapped the fine genetic structure of the pabA gene and discovered polarized negative interference in crossing-over. Later he showed that recombinant bacteria inherit labeled DNA of biparental origin. Siddiqi and his colleagues demonstrated that recombinant molecules can arise from conserved unreplicated DNA. In 1961, Siddiqi and Garen discovered suppressor of nonsense mutations in the gene for alkaline phosphatase. This work led to the elucidation of the stop codons in the genetic code and the mechanism of chain termination during protein synthesis.
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