Cast
- Eddie Murphy as Professor Sherman Klump / Buddy Love / Granny Klump / Mama Anna Klump / Papa Cletus Klump / Young Papa Cletus Klump / Ernie Klump / Lance Perkins
- Janet Jackson as Denise Gaines. Gaines replaces Sherman's girlfriend in the first film, Carla Purty because the actress who played her, Jada Pinkett left due to marrying rapper-turned-actor Will Smith, her pregnancy and later her signing on to the sequels to The Matrix
- Larry Miller as Dean Richmond
- John Ales as Jason
- Richard Gant as Mr. Gaines
- Anna Maria Horsford as Mrs. Gaines
- Melinda McGraw as Leanne Guilford
- Jamal Mixon as Ernie Klump Jr.
- Wanda Sykes as Chantal
- Freda Payne as Claudine
- Nikki Cox as Student
- Chris Elliott as Restaurant Manager
- Duffy Taylor as Restaurant Trainee
- Earl Boen as Dr. Knoll
- Charles Napier as Four Star General
- Steve Kehela as Scientist
- Miguel A Nunez Jr. as Scientist
- Viola Kates Stimpson as Sweet Old Lady with Dog
Read more about this topic: Nutty Professor II: The Klumps
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