NER Associated Genes
| Human Gene (Protein) | Mouse Ortholog | Yeast Ortholog | Subpathway | Function in NER | GeneCards Entry |
|---|---|---|---|---|---|
| CCNH (Cyclin H) | Ccnh | CCL1 | Both | CDK Activator Kinase (CAK) subunit | CCNH |
| CDK7 (Cyclin Dependent Kinase (CDK) 7)) | Cdk7 | KIN28 | Both | CDK7 | |
| CETN2 (Centrin-2) | Cetn2 | Unknown | GGR | damage recognition; forms complex with XPC | CETN2 |
| DDB1 (DDB1) | Ddb1 | Unknown | GGR | damage recognition; forms complex with DDB2 | DDB1 |
| DDB2 (DDB2) | Ddb2/Xpe | Unknown | GGR | damage recognition; recruits XPC | DDB2 |
| ERCC1 (ERCC1) | Ercc1 | RAD10 | Both | Involved in incision on 3' side of damage; forms complex with XPF | ERCC1 |
| ERCC2 (XPD) | Ercc2 | RAD3 | Both | ATPase and helicase activity; transcription factor II H (TFIIH) subunit | ERCC2 |
| ERCC3 (XPB) | Ercc3 | RAD25 | Both | ATPase and helicase activity; transcription factor II H (TFIIH) subunit | ERCC3 |
| ERCC4 (XPF) | Ercc4 | RAD1 | Both | Involved in incision on 3' side of damage; structure specific endonuclease | ERCC4 |
| ERCC5 (XPG) | Ercc5 | RAD2 | Both | Involved in incision on 5' side of damage; stabilizes TFIIH; structure specific endonuclease | ERCC5 |
| ERCC6 (CSB) | Ercc6 | RAD26 | TC-NER | transcription elongation factor; involved in transcription coupling and chromatin remodelling | ERCC6 |
| ERCC8 (CSA) | Ercc8 | RAD28 | TC-NER | ubiquitin ligase complex; interacts with CSB and p44 of TFIIH | ERCC8 |
| LIG1 (DNA Ligase I) | Lig1 | CDC9 | Both | LIG1 | |
| MNAT1 (MNAT1) | Mnat1 | TFB3 | Both | Stabilizes CAK complex | MNAT1 |
| MMS19 (MMS19) | Mms19 | MET18 | Both | Interacts with XPD and XPB subunits of TFIIH helicases | MMS19 |
| RAD23A (RAD23A) | Rad23a | RAD23 | GGR | damage recognition; forms complex with XPC | RAD23A |
| RAD23B (RAD23B) | Rad23b | RAD23 | GGR | damage recognition, forms complex with XPC | RAD23B |
| RPA1 (RPA1) | Rpa1 | RFA1 | Both | subunit of RFA complex | RPA1 |
| RPA2 (RPA2) | Rpa2 | RFA2 | Both | subunit of RFA complex | RPA2 |
| TFIIH (Transcription factor II H) | Unknown | Unknown | Both | No GeneCards | |
| XAB2 (XAB2) | Xab2 | SYF1 | TC-NER | damage recognition; interacts with XPA, CSA, and CSB | XAB2 |
| XPA (XPA) | Xpa | RAD14 | Both | damage recognition | XPA |
| XPC (XPC) | Xpc | RAD4 | GGR | damage recognition | XPC |
Read more about this topic: Nucleotide Excision Repair
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