Stage
Mwine began appearing in stage productions in 1992, appearing as the conman posing as the son of Sidney Poitier in Six Degrees of Separation, and in The Riddles Of Race, Circa '68 in 1994, In 1992 and 1997, Mwine was nominated for a Helen Hayes Award for Outstanding Lead Actor in a Non-Resident Production, for his part in "Six Degrees of Separation" at The National Theatre and Nomathemba — at the Kennedy Center in Washington D.C.. He played Julius Van George in Scent of the Roses at the Seattle Contemporary Theatre in 1998.
His first effort as a playwright, a barestage one-man show entitled Biro, about a HIV-positive Ugandan former rebel soldier who enters the United States illegally for treatment. The play, based on a 90-minute explanation from the eponymous character to his lawyer about how he came to be in a Texas jail cell, premiered in early 2003 at Uganda's National Theatre, before showing at the Joseph Papp Public Theater in New York, as well as in Los Angeles, Seattle, London, and throughout Africa. He performed it in front of multiple African heads of state and then-UN General Secretary Kofi Annan in 2004. The Seattle Post-Intelligencer described his performance as "radiant", particularly so given the dark subject matter.
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