NPU may mean:
- National Power Unity
- Neighborhood Planning Unit
- Net protein utilization
- Network Processing Unit
- Nine Percent Unknown Glasgow, Scotland Pop Punk Band
- Northwestern Polytechnical University, Xi'an, Shaanxi, China
- Northwestern Polytechnic University, Fremont, California, USA
- North Park University. Chicago, Illinois, USA
- National Penghu University. Penghu, Taiwan