Notch Signaling in Central Nervous System Development and Function
Early findings on Notch signaling in Central Nervous System (CNS) development were mainly performed in Drosophila with mutagenesis experiments. For example, the finding that an embryonic lethal phenotype in Drosophila was associated with Notch dysfunction indicated that Notch mutations can lead to the failure of neural and Epidermal cell segregation in early Drosophila embryos. In the past decade, advances in mutation and knockout techniques allowed research on the Notch signaling pathway in mammalian models, especially rodents.
The Notch signaling pathway was mainly found to be critical for neural progenitor cell (NPC) maintenance and self-renewal. In recent years, other functions of the Notch pathway have also been found, including glial cell specification, neurites development as well as learning and memory.
Read more about this topic: Notch Signaling Pathway
Famous quotes containing the words notch, central, nervous, system, development and/or function:
“Father Time is not always a hard parent, and, though he tarries for none of his children, often lays his hand lightly upon those who have used him well; making them old men and women inexorably enough, but leaving their hearts and spirits young and in full vigour. With such people the grey head is but the impression of the old fellow’s hand in giving them his blessing, and every wrinkle but a notch in the quiet calendar of a well- spent life.”
—Charles Dickens (1812–1870)
“Parental attitudes have greater correlation with pupil achievement than material home circumstances or variations in school and classroom organization, instructional materials, and particular teaching practices.”
—Children and Their Primary Schools, vol. 1, ch. 3, Central Advisory Council for Education, London (1967)
“I cannot exaggerate the waste of the President’s time and the consumption of his nervous vitality involved in listening to congressmen’s intercession as to local appointments. Why should the President have to have his time taken up in a discussion over ... who shall be the postmistress of Devil’s Lake, in North Dakota? How should he be able to know ... who is best fitted to fill such a place?”
—William Howard Taft (1857–1930)
“We are now going through a period of demolition. In morals, in social life, in politics, in medicine, and in religion there is a universal upturning of foundations. But the day of reconstruction seems to be looming, and now the grand question is: Are there any sure and universal principles that will evolve a harmonious system in which we shall all agree?”
—Catherine E. Beecher (1800–1878)
“The proper aim of education is to promote significant learning. Significant learning entails development. Development means successively asking broader and deeper questions of the relationship between oneself and the world. This is as true for first graders as graduate students, for fledging artists as graying accountants.”
—Laurent A. Daloz (20th century)
“... the function of art is to do more than tell it like it is—it’s to imagine what is possible.”
—bell hooks (b. c. 1955)