Notch Signaling in Central Nervous System Development and Function
Early findings on Notch signaling in Central Nervous System (CNS) development were mainly performed in Drosophila with mutagenesis experiments. For example, the finding that an embryonic lethal phenotype in Drosophila was associated with Notch dysfunction indicated that Notch mutations can lead to the failure of neural and Epidermal cell segregation in early Drosophila embryos. In the past decade, advances in mutation and knockout techniques allowed research on the Notch signaling pathway in mammalian models, especially rodents.
The Notch signaling pathway was mainly found to be critical for neural progenitor cell (NPC) maintenance and self-renewal. In recent years, other functions of the Notch pathway have also been found, including glial cell specification, neurites development as well as learning and memory.
Read more about this topic: Notch Signaling Pathway
Famous quotes containing the words notch, central, nervous, system, development and/or function:
“Father Time is not always a hard parent, and, though he tarries for none of his children, often lays his hand lightly upon those who have used him well; making them old men and women inexorably enough, but leaving their hearts and spirits young and in full vigour. With such people the grey head is but the impression of the old fellow’s hand in giving them his blessing, and every wrinkle but a notch in the quiet calendar of a well- spent life.”
—Charles Dickens (1812–1870)
“For us necessity is not as of old an image without us, with whom we can do warfare; it is a magic web woven through and through us, like that magnetic system of which modern science speaks, penetrating us with a network subtler than our subtlest nerves, yet bearing in it the central forces of the world.”
—Walter Pater (1839–1894)
“He was the finest of our happy men;
He had all joys, he never thought of death;
He fiddled sometimes with his mind, and then
Shook off the tremor like a nervous wren....”
—Allen Tate (1899–1979)
“Each generation’s job is to question what parents accept on faith, to explore possibilities, and adapt the last generation’s system of values for a new age.”
—Frank Pittman (20th century)
“The work of adult life is not easy. As in childhood, each step presents not only new tasks of development but requires a letting go of the techniques that worked before. With each passage some magic must be given up, some cherished illusion of safety and comfortably familiar sense of self must be cast off, to allow for the greater expansion of our distinctiveness.”
—Gail Sheehy (20th century)
“The fact remains that the human being in early childhood learns to consider one or the other aspect of bodily function as evil, shameful, or unsafe. There is not a culture which does not use a combination of these devils to develop, by way of counterpoint, its own style of faith, pride, certainty, and initiative.”
—Erik H. Erikson (1904–1994)