Notch Signaling in Central Nervous System Development and Function
Early findings on Notch signaling in Central Nervous System (CNS) development were mainly performed in Drosophila with mutagenesis experiments. For example, the finding that an embryonic lethal phenotype in Drosophila was associated with Notch dysfunction indicated that Notch mutations can lead to the failure of neural and Epidermal cell segregation in early Drosophila embryos. In the past decade, advances in mutation and knockout techniques allowed research on the Notch signaling pathway in mammalian models, especially rodents.
The Notch signaling pathway was mainly found to be critical for neural progenitor cell (NPC) maintenance and self-renewal. In recent years, other functions of the Notch pathway have also been found, including glial cell specification, neurites development as well as learning and memory.
Read more about this topic: Notch Signaling Pathway
Famous quotes containing the words notch, central, nervous, system, development and/or function:
“Father Time is not always a hard parent, and, though he tarries for none of his children, often lays his hand lightly upon those who have used him well; making them old men and women inexorably enough, but leaving their hearts and spirits young and in full vigour. With such people the grey head is but the impression of the old fellow’s hand in giving them his blessing, and every wrinkle but a notch in the quiet calendar of a well- spent life.”
—Charles Dickens (1812–1870)
“Sweet weight,
in celebration of the woman I am
and of the soul of the woman I am
and of the central creature and its delight
I sing for you. I dare to live.”
—Anne Sexton (1928–1974)
“I can’t accept “our nervous age,” since mankind has been nervous during every age. Whoever fears nervousness should turn into a sturgeon or smelt; if a sturgeon makes a stupid mistake, it can only be one: to end up on a hook, and then in a pan in a pastry shell.”
—Anton Pavlovich Chekhov (1860–1904)
“When the finishing stroke was put to his work, it suddenly expanded before the eyes of the astonished artist into the fairest of all the creations of Brahma. He had made a new system in making a staff, a world with full and fair proportions; in which, though the old cities and dynasties had passed away, fairer and more glorious ones had taken their places.”
—Henry David Thoreau (1817–1862)
“John B. Watson, the most influential child-rearing expert [of the 1920s], warned that doting mothers could retard the development of children,... Demonstrations of affection were therefore limited. “If you must, kiss them once on the forehead when they say goodnight. Shake hands with them in the morning.””
—Sylvia Ann Hewitt (20th century)
“The more books we read, the clearer it becomes that the true function of a writer is to produce a masterpiece and that no other task is of any consequence.”
—Cyril Connolly (1903–1974)