Notch Signaling in Central Nervous System Development and Function
Early findings on Notch signaling in Central Nervous System (CNS) development were mainly performed in Drosophila with mutagenesis experiments. For example, the finding that an embryonic lethal phenotype in Drosophila was associated with Notch dysfunction indicated that Notch mutations can lead to the failure of neural and Epidermal cell segregation in early Drosophila embryos. In the past decade, advances in mutation and knockout techniques allowed research on the Notch signaling pathway in mammalian models, especially rodents.
The Notch signaling pathway was mainly found to be critical for neural progenitor cell (NPC) maintenance and self-renewal. In recent years, other functions of the Notch pathway have also been found, including glial cell specification, neurites development as well as learning and memory.
Read more about this topic: Notch Signaling Pathway
Famous quotes containing the words notch, central, nervous, system, development and/or function:
“In any weather, at any hour of the day or night, I have been anxious to improve the nick of time, and notch it on my stick too; to stand on the meeting of two eternities, the past and the future, which is precisely the present moment; to toe that line.”
—Henry David Thoreau (1817–1862)
“Incarnate devil in a talking snake,
The central plains of Asia in his garden,
In shaping-time the circle stung awake,
In shapes of sin forked out the bearded apple....”
—Dylan Thomas (1914–1953)
“A car can massage organs which no masseur can reach. It is the one remedy for the disorders of the great sympathetic nervous system.”
—Jean Cocteau (1889–1963)
“Few white citizens are acquainted with blacks other than those projected by the media and the so—called educational system, which is nothing more than a system of rewards and punishments based upon one’s ability to pledge loyalty oaths to Anglo culture. The media and the “educational system” are the prime sources of racism in the United States.”
—Ishmael Reed (b. 1938)
“Women, because of their colonial relationship to men, have to fight for their own independence. This fight for our own independence will lead to the growth and development of the revolutionary movement in this country. Only the independent woman can be truly effective in the larger revolutionary struggle.”
—Women’s Liberation Workshop, Students for a Democratic Society, Radical political/social activist organization. “Liberation of Women,” in New Left Notes (July 10, 1967)
“The function of the actor is to make the audience imagine for the moment that real things are happening to real people.”
—George Bernard Shaw (1856–1950)