Major Intersections
| County | Location | Mile | Destinations | Notes | |
|---|---|---|---|---|---|
| Stokes | Walnut Cove | 0.0 | US 311 (Main Street) – Winston-Salem, Madison | Southern terminus | |
| Meadows | 5.1 | NC 8 south – Winston-Salem, Lexington | South end of concurrency with NC 8 | ||
| Danbury | 11.7 | NC 8 north – Lawsonville | North end of concurrency with NC 8 | ||
| Francisco | 19.9 | NC 704 east (Wesley D. Webster Highway) – Delta | Western terminus of NC 704 | ||
| Johnstown | 25.4 | NC 66 south – Rural Hall, Walkertown | Northern terminus of NC 66 | ||
| Surry | Mt. Airy | 38.6 | US 52 Bus. south (Main Street) |
South end of concurrency with Business US 52 | |
| 39.9 | US 52 Bus. north (Renfro Street) / NC 103 east (Pine Street) – Flat Rock |
North end of concurrency with Business US 52; Western terminus of NC 103 | |||
| 40.8 | US 52 (Andy Griffith Parkway) to US 601 south (Rockford Street) – Rural Hall, Fancy Gap, VA, Boonville | Partial diamond interchange | |||
| 47.2 | I-74 (C. Richard Vaughn Highway) – White Plains | Partial cloverleaf interchange | |||
| 48.5 | I-77 (Charles M. Shelton Parkway) – Jonesville, Wytheville, VA | Partial cloverleaf interchange | |||
| Lowgap | 60.8 | NC 18 south – Sparta, Wilkesboro | Northern terminus of NC 18 | ||
| Virginia state line | 61.1 | SR 89 north (Skyline Highway) – Galax | Northern terminus | ||
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