Major Intersections
| County | Location | Mile | Destinations | Notes | |
|---|---|---|---|---|---|
| Orange | Chapel Hill | 0.0 | US 15 / US 501 / NC 54 (Fordham Boulevard) – Fearrington, Durham, Carrboro | Southern terminus; Diamond interchange | |
| 5.6 | I-40 (Harriet Morehead Berry Freeway) – Burlington, Raleigh | Diamond interchange; Exit 266 | |||
| Hillsborough | 12.3 | I-85 – Graham, Durham | Diamond interchange; Exit 165 | ||
| 13.0 | US 70 Bus. east |
South end of concurrency with Business US 70 | |||
| 14.7 | US 70 Bus. west (Corbin Street) |
North end of concurrency with Business US 70 | |||
| 15.0 | US 70 (Cornelius Street) – Burlington, Durham | ||||
| 15.3 | NC 57 north – Caldwell, Roxboro | Southern terminus of NC 57 | |||
| 27.2 | NC 49 south – Haw River, Graham | South end of concurrency with NC 49 | |||
| Caswell | Prospect Hill | 27.7 | NC 49 north – Roxboro | North end of concurrency with NC 49 | |
| Hightowers | 34.5 | NC 119 – Mebane, Semora | |||
| 39.2 | US 158 east – Roxboro | South end of concurrency with US 158 | |||
| Yanceyville | 42.1 - 42.3 |
NC 62 – Jericho, Milton | Brief 0.2 mile concurrency | ||
| 44.4 | US 158 west – Casville | North end of concurrency with US 158 | |||
| Virginia state line | 53.4 | SR 86 north (Main Street) to US 29 / US 58 (Danville Expressway) – Danville | Northern terminus | ||
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Read more about this topic: North Carolina Highway 86
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