NLR may mean:
- Nazi Low Riders
- National LambdaRail, a high-speed computer network
- National Aerospace Laboratory - NLR
- Newark Light Rail
- New Left Review
- Northampton & Lamport Railway
- North London Railway, Historical information
- North London Railway, Current information
- North Little Rock, AR, city in Arkansas
- NOD-like receptor, a family of intracellular receptors
- New Leaf Radio, a radio station centered in Des Moines, Iowa
- New Lunar Republic, a fan-created "faction" from My Little Pony: Friendship is Magic