NFE2L2
Gene Ontology | |
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Molecular function | • RNA polymerase II activating transcription factor binding • DNA binding • sequence-specific DNA binding transcription factor activity • protein domain specific binding • sequence-specific DNA binding |
Cellular component | • chromatin • nucleus • cytoplasm • centrosome • cytosol • plasma membrane |
Biological process | • transcription from RNA polymerase II promoter • proteasomal ubiquitin-independent protein catabolic process • protein ubiquitination • positive regulation of blood coagulation • endoplasmic reticulum unfolded protein response • positive regulation of transcription from RNA polymerase II promoter in response to stress • negative regulation of apoptotic process • proteasomal ubiquitin-dependent protein catabolic process • regulation of embryonic development • cellular response to hydrogen peroxide • cellular response to laminar fluid shear stress • regulation of removal of superoxide radicals • positive regulation of reactive oxygen species metabolic process |
Sources: Amigo / QuickGO |
178.09 – 178.26 Mb
75.68 – 75.7 Mb
Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene. The Nrf2 antioxidant response pathway is "the primary cellular defense against the cytotoxic effects of oxidative stress." Among other effects, NFE2L2 increases the expression of several antioxidant enzymes. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress, and dimethyl fumarate significantly reduced the progression of disability in multiple sclerosis
Read more about NFE2L2: Function, Target Genes, Structure, Tissue Distribution, Nrf2 As A Drug Target, Interactions