Major Intersections
The entire route is in Erie County.
| Location | Mile | km | Destinations | Notes |
|---|---|---|---|---|
| Collins | 0.00 | 0.00 | NY 39 | Hamlet of Collins Center |
| Town of North Collins | 6.62 | 10.65 | NY 249 | Hamlet of Langford; eastern terminus of NY 249 |
| Eden | 14.35 | 23.09 | US 62 south | Southern terminus of US 62 / NY 75 overlap |
| Village of Hamburg | 16.29 | 26.22 | US 62 north | Northern terminus of US 62 / NY 75 overlap |
| Town of Hamburg | 18.22 | 29.32 | I-90 / Thruway | Exit 57 (I-90 / Thruway) |
| 18.97 | 30.53 | US 20 | ||
| 20.85 | 33.55 | NY 5 | Hamlet of Athol Springs |
Read more about this topic: New York State Route 75
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—Elaine Heffner (20th century)