Life Span
The average lifespan of (non-activated human) neutrophils in the circulation is about 5.4 days. Upon activation, they marginate (position themselves adjacent to the blood vessel endothelium), and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1–2 days.
Neutrophils are much more numerous than the longer-lived monocyte/macrophage phagocytes. A pathogen (disease-causing microorganism or virus) is likely to first encounter a neutrophil. Some experts hypothesize that the short lifetime of neutrophils is an evolutionary adaptation. The short lifetime of neutrophils minimizes propagation of those pathogens that parasitize phagocytes because the more time such parasites spend outside a host cell, the more likely they will be destroyed by some component of the body's defenses. Also, because neutrophil antimicrobial products can also damage host tissues, their short life limits damage to the host during inflammation.
Neutrophils will often be phagocytosed themselves by macrophages after digestion of pathogens. PECAM-1 and phosphatidylserine on the cell surface are involved in this process.
Read more about this topic: Neutrophil Granulocyte
Famous quotes by life span:
“I’ve seen things you people wouldn’t believe. Attack ships on fire off the shoulder of Orion. I watched seabeams glitter in the dark near the Tennhauser Gate. All those moments will be lost in time like tears in rain. Time to die.”
—David Webb Peoples, U.S. screenwriter, and Ridley Scott. Roy Batty, Blade Runner, final words before dying—as an android he had a built-in life span that expired (1982)