History
This idea was first presented in 2002 by Uri Alon and his group when network motifs were discovered in the gene regulation (transcription) network of the bacteria E. coli and then in a large set of natural networks.Since then, a considerable number of researches have been conducted on this subject. Some of these researches focus on the biological aspects and others work on computational facets. The first group endeavors to interpret the motifs detected for biological networks by the existing motif detection tools. For example, in work following, the network motifs found in E. coli were discovered in the transcription networks of other bacteria as well as yeast and higher organisms. A distinct set of network motifs were identified in other types of biological networks such as neuronal networks and protein interaction networks.
The second group of researches tries to improve the existing motif detection tools to make faster results on larger networks possible for researchers of the first group. Different algorithms are provided for this aim so far. These are elaborated in the next section in chronological order.
Recently, acc-MOTIF tool to detect network motifs became available.
Read more about this topic: Network Motif
Famous quotes containing the word history:
“They are a sort of post-house,where the Fates
Change horses, making history change its tune,
Then spur away o’er empires and o’er states,
Leaving at last not much besides chronology,
Excepting the post-obits of theology.”
—George Gordon Noel Byron (1788–1824)
“It gives me the greatest pleasure to say, as I do from the bottom of my heart, that never in the history of the country, in any crisis and under any conditions, have our Jewish fellow citizens failed to live up to the highest standards of citizenship and patriotism.”
—William Howard Taft (1857–1930)
“I believe that in the history of art and of thought there has always been at every living moment of culture a “will to renewal.” This is not the prerogative of the last decade only. All history is nothing but a succession of “crises”Mof rupture, repudiation and resistance.... When there is no “crisis,” there is stagnation, petrification and death. All thought, all art is aggressive.”
—Eugène Ionesco (b. 1912)