Nerve Growth Factor Receptor
Nerve growth factor receptors are a group of growth factor receptors which specifically bind to neurotrophins.
There are two classes of receptors, p75 and the "Trk" family of Tyrosine kinases receptors.
- p75 is a low affinity neurotrophin receptor, to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase "x" only applies to this receptor.
- The Trk family include TrkA, TrkB, and TrkC, and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins.
- NGF binds to TrkA, BDNF and NT-4 bind to TrkB and NT-3 binds to TrkC. In addition NT-3 also binds to and activates TrkA and TrkB but it does so less efficiently.
- Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis.
Read more about Nerve Growth Factor Receptor: TrkA, B, and C Receptors, LNGFR Receptor
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