Structure
The structure of NGF was first solved by X-ray crystallography and published in 1991 by McDonald et al. in Nature. NGF forms a cystine knot structure made up of beta strands twisted around each other and linked by disulfide bonds. Most structures are dimeric. At the time this structure was solved, this fold had never been seen before. Hence NGF is the founding member of the nerve growth factor family of structurally conserved proteins.
Read more about this topic: Nerve Growth Factor
Famous quotes containing the word structure:
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For this blank cold, this sadness without cause.
The great structure has become a minor house.
No turban walks across the lessened floors.
The greenhouse never so badly needed paint.”
—Wallace Stevens (1879–1955)
“For the structure that we raise,
Time is with materials filled;
Our to-days and yesterdays
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—Henry Wadsworth Longfellow (1809–1882)
“A special feature of the structure of our book is the monstrous but perfectly organic part that eavesdropping plays in it.”
—Vladimir Nabokov (1899–1977)