Natsume (なつめ, ナツメ?) can refer to:
- the Jujube fruit
- A type of chaki (tea caddy) used in Japanese tea ceremony
- Natsume (company), a Japanese video game developer
- Natsume Sōseki, a famous 19th century Japanese novelist
- Masako Natsume, a Japanese actor
- Rio Natsume, a Japanese gravure idol
- Natsume, a Pokémon character renamed Sabrina in the English version
- Natsume Hyūga, a character in the anime/manga series Alice Academy
- Natsume Sano, a Japanese gravure idol
- Natsume Takashi, the title character in the manga and anime series Natsume's Book of Friends
- Maya Natsume, a character in the anime Tenjho Tenge