Research History
After qualifying in medicine in 1946, Datta joined the Public Health Laboratory Service as a bacteriologist and worked here for ten years. She then worked at the Royal Postgraduate Medical School at Hammersmith Hospital for almost three decades, joining as a lecturer in 1957 and later becoming Professor of Microbial Genetics. It was here that she made a significant breakthrough by demonstrating that antibiotic resistance could be transmitted between bacteria, the first time this had been shown outside of Japan.
In 1959 there was a severe outbreak of Salmonella typhimurium phage-type 27 and, as part of her research at Hammersmith Hospital, Datta examined 309 cultures to see if the strain was unaltered after moving through hosts. 25 of the 309 were found to be drug-resistant, eight of which were resistant to Streptomycin which had been used to treat the patients. Notably, Datta observed that earlier cultures of the salmonella typhimurium infection (from the start of the outbreak) were not drug-resistant, so it seemed that the antibiotic resistance had developed over time.
Datta published these findings in 1960, in the paper An outbreak of infection with Salmonella typhimurium in a general hospital, and later in 1962 in the paper Transmissible drug resistance in an epidemic strain of Salmonella typhimurium in the Journal of Hygiene.
In later years she published many important studies on the occurrence and significance of drug resistance plasmids in enterobacterial infections. For example, Dr. Datta co-authored (with Royston C. Clowes, Stanley Cohen, Roy Curtiss III, Stanley Falkow and Richard Novick) a proposal for uniform nomenclature for bacterial plasmids.
She also made distinguished contributions to research on the molecular biology of R factors, and she pioneered the classification of R factors and other plasmids by their incompatibilities. She found that some resistance genes, including those for gentamycin resistance, are located on transposons and are readily transferred between replicons.
Read more about this topic: Naomi Datta
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