Physiology
The gene for MOG, found on chromosome 6p21.3-p22, was first sequenced in 1995. It is a transmembrane protein expressed on the surface of oligodendrocyte cell and on the outermost surface of myelin sheaths. “MOG is a quantitatively minor type I transmembrane protein, and is found exclusively in the CNS. “A single Ig-domain is exposed to the extracellular space" and consequently allows autoantibodies easy access. and therefore easily accessible for autoantibodies. The MOG “primary nuclear transcript … is 15,561 nucleotides in length" and, for humans, it has eight exons which are “separated by seven introns". The introns "contain numerous reptitive DNA" sequences, among which is "14 Alu sequences within 3 introns", and have a range varying from 242 to 6484 bp.
Read more about this topic: Myelin Oligodendrocyte Glycoprotein
Famous quotes containing the word physiology:
“A physician’s physiology has much the same relation to his power of healing as a cleric’s divinity has to his power of influencing conduct.”
—Samuel Butler (1835–1902)
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“Now the twitching stops. Now you are still. We are through with physiology and theology, physics begins.”
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