Mutsu may refer to:
- Mutsu, Aomori, a city in Aomori prefecture, Japan
- Mutsu Province, one of the old provinces of Japan
- Mutsu (ship), a merchant ship that was Japan's only nuclear-powered ship
- Japanese battleship Mutsu, a battleship of the Imperial Japanese Navy
- Mutsu Munemitsu, a diplomat in Japan during the Meiji period
- Iso Mutsu, author of the first guide to Kamakura ever written
- Bluefish, a sushi/sashimi ingredient
- Mutsu (apple), a yellow-gold apple also known as Crispin
- Mutsu (toy), a toy made by Tomy Japan. The toy was also released in America.
- The fictional Mutsu clan in the manga and anime series Shura no Toki - Age of Chaos
- Mutsu, Estonia, a village in Vastseliina Parish, Võru County, Estonia