Comparison Table
Substance | Trade names | Mechanism | Clinical use | Adverse effects |
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Atropine (D/L-Hyoscyamine) | non-selective antagonism, CNS depression |
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Scopolamine (L-Hyoscine) | Scopace, Transderm-Scop, Maldemar, Buscopan | non-selective antagonism, CNS depression |
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Hydroxyzine | Vistaril, Atarax | |||
Ipratropium | Atrovent and Apovent | non-selective antagonism, without any mucociliary excretion inhibition. |
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Tropicamide | short acting non-selective antagonism, CNS depression |
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Pirenzepine | M1 receptor-selective antagonist
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(fewer than non-selective ones) | |
Diphenhydramine | Benadryl, Sominex | Non-selective antagonism in the central nervous system, blood vessels and smooth muscle tissues |
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*Sedation, dry mouth, constipation, urinary retention |
Dimenhydrinate | Dramamine | Combination of diphenhydramine with a methylxanthine salt |
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Dicyclomine | ||||
Flavoxate | Urispas |
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Oxybutynin | Ditropan |
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Tiotropium | Spiriva |
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Cyclopentolate | short acting non-selective antagonism, CNS depression |
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Atropine methonitrate | non-selective antagonism, blocks transmission in ganglia. Lacks CNS effects |
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Trihexyphenidyl/Benzhexol | Artane | Targets the M1 Muscarinic receptor | Parkinson's disease | Drug at relative dose has 83% activity of atropine, thus has the same side-effects |
Tolterodine | Detrusitol, Detrol | |||
Solifenacin | Vesicare | Competitive muscarinic acetylcholine receptor antagonist |
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Darifenacin | Enablex | Selective for M3 receptors | Urinary incontinence | Few side effects |
Benzatropine | Cogentin | Reduces the effects of the relative central cholinergic excess that occurs as a result of dopamine deficiency. | Parkinson's disease | |
Mebeverine | Colofac, Duspatal, Duspatalin | A muscolotropic spasmolytic with a strong and selective action on the smooth muscle spasm of the gastrointestinal tract, particularly of the colon. |
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Procyclidine | Antimuscarinic |
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Overdose produces confusion, agitation and sleeplessness that can last up to or more than 24 hours. Pupils become dilated and unreactive to light. Tachycardia (fast heart beat), as well as auditory and visual hallucinations |
Read more about this topic: Muscarinic Antagonist
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