Mulroney is a surname of Irish origin. The name refers to:
- Family of Brian Mulroney (born 1939), Progressive Conservative Prime Minister of Canada 1984–1993
- Mila Mulroney (b. 1953), wife of Brian Mulroney
- Caroline Mulroney (b. 1974), daughter of Brian Mulroney
- Ben Mulroney (b. 1976), son of Brian Mulroney; Canadian television host
- Other persons
- Kieran Mulroney (b. 1965), American television actor and musician
- Dermot Mulroney (b. 1963), American actor