Moxy or Moxie may refer to:
- Moxie, a carbonated beverage originating from the late 19th century
- Moxy (band), a Canadian hard rock band formed in the 1970s
- Moxy (singer), performer of theme music for Ben 10
- Moxy (sneaker boots), a type of shoe made by Cherry Avenue
- Moxy Engineering, a Norwegian dump truck manufacturer
- Moxy Früvous, a Canadian folk-pop/geek-rock band
- The Moxy Show, Cartoon Network's first original series
- Moxy (slang), name for the research chemical 5-MeO-MIPT
- MOXy, the EclipseLink implementation of JAXB