Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.
SMAD7 is a protein that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members, SMAD7 is involved in cell signalling. It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is enhanced by SMURF2.
Smad7 enhances muscle differentiation.
Famous quotes containing the word mothers:
“Many women who used to be full-time mothers are discovering that outside work gives them friends, challenges, variety, money, independence; it makes them feel better about themselves, and therefore lets them be better parents.”
—Wendy Coppedge Sanford. Ourselves and Our Children, by Boston Womens Health Book Collective, introduction (1978)