Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.
SMAD7 is a protein that, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of ligands. Like many other TGFβ family members, SMAD7 is involved in cell signalling. It is a TGFβ type 1 receptor antagonist. It blocks TGFβ1 and activin associating with the receptor, blocking access to SMAD2. It is an inhibitory SMAD (I-SMAD) and is enhanced by SMURF2.
Smad7 enhances muscle differentiation.
Read more about Mothers Against Decapentaplegic Homolog 7: Structure, Function, Role in Cancer, Interactions
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“However diligent she may be, however dedicated, no mother can escape the larger influences of culture, biology, fate . . . until we can actually live in a society where mothers and children genuinely matter, ours is an essentially powerless responsibility. Mothers carry out most of the work orders, but most of the rules governing our lives are shaped by outside influences.”
—Mary Kay Blakely (20th century)