Monoclonal gammopathy is a synonym for paraproteinemia. These are usually found in association with haemic neoplasms, especially multiple myeloma. They also occur in other benign and malignant conditions.
|
Immune disorders, Immunoproliferative immunoglobulin disorders (D89, 273)
|
|
| PCDs/PP |
Plasmacytoma · Multiple myeloma (Plasma cell leukemia) · MGUS · IgM (Macroglobulinemia/Waldenström's macroglobulinemia) · heavy chain (Heavy chain disease) · light chain (Primary amyloidosis)
|
|
| Other hypergammaglobulinemia |
Cryoglobulinemia
|
|
|
M: LMC
|
cell/phys/auag/auab/comp, igrc
|
imdf/ipig/hyps/tumr
|
proc, drug (L3/4)
|
|
|
|
Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)
|
|
B cell
(lymphoma,
leukemia)
(most CD19
|
By development/
marker
|
|
TdT+
|
- ALL (Precursor B acute lymphoblastic leukemia/lymphoma)
|
|
|
CD5+
|
mantle zone (Mantle cell)
|
|
|
CD22+
|
- Prolymphocytic
- CD11c+ (Hairy cell leukemia)
|
|
|
CD79a+
|
- germinal center/follicular B cell (Follicular
- Burkitt's
- GCB DLBCL
- Primary cutaneous follicular lymphoma)
marginal zone/marginal-zone B cell (Splenic marginal zone
- MALT
- Nodal marginal zone
- Primary cutaneous marginal zone lymphoma)
|
|
|
RS (CD15+, CD30+)
|
- Classic Hodgkin's lymphoma (Nodular sclerosis)
- CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)
|
|
PCDs/PP
(CD38+/CD138+)
|
- see immunoproliferative immunoglobulin disorders
|
|
|
|
By infection
|
- KSHV (Primary effusion)
- EBV (Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder)
- HIV (AIDS-related lymphoma)
- Helicobacter pylori (MALT lymphoma)
|
|
|
Cutaneous
|
- Diffuse large B-cell lymphoma
- Intravascular large B-cell lymphoma
- Primary cutaneous marginal zone lymphoma
- Primary cutaneous immunocytoma
- Plasmacytoma
- Plasmacytosis
- Primary cutaneous follicular lymphoma
|
|
|
|
T/NK
|
T cell
(lymphoma,
leukemia)
(most CD3
|
By development/
marker
|
- TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)
- prolymphocyte (Prolymphocytic)
- CD30+ (Anaplastic large-cell lymphoma
- Lymphomatoid papulosis type A)
|
|
|
Cutaneous
|
|
MF+variants
|
- indolent: Mycosis fungoides
- Pagetoid reticulosis
- Granulomatous slack skin
aggressive: Sézary's disease
- Adult T-cell leukemia/lymphoma
|
|
|
Non-MF
|
- CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
- Pleomorphic T-cell lymphoma
- Lymphomatoid papulosis type B
CD30+: CD30+ cutaneous T-cell lymphoma
- Secondary cutaneous CD30+ large cell lymphoma
- Lymphomatoid papulosis type A
|
|
|
|
Other peripheral
|
- Hepatosplenic
- Angioimmunoblastic
- Enteropathy-associated T-cell lymphoma
- Peripheral T-cell lymphoma-Not-Otherwise-Specified (Lennert lymphoma)
- Subcutaneous T-cell lymphoma
|
|
|
By infection
|
- HTLV-1 (Adult T-cell leukemia/lymphoma)
|
|
|
NK cell/
(most CD56)
|
- Aggressive NK-cell leukemia
- Blastic NK cell lymphoma
|
|
|
T or NK
|
- EBV (Extranodal NK-T-cell lymphoma/Angiocentric lymphoma)
- Large granular lymphocytic leukemia
|
|
|
|
Lymphoid+myeloid
|
- Acute biphenotypic leukaemia
|
|
|
Lymphocytosis
|
- Lymphoproliferative disorders (X-linked lymphoproliferative disease
- Autoimmune lymphoproliferative syndrome)
- Leukemoid reaction
- Diffuse infiltrative lymphocytosis syndrome
|
|
|
| Cutaneous lymphoid hyperplasia |
- Cutaneous lymphoid hyperplasia with bandlike and perivascular patterns
- Cutaneous lymphoid hyperplasia with nodular pattern
- Jessner lymphocytic infiltrate of the skin
|
|
|
M: LMC
|
cell/phys/auag/auab/comp, igrc
|
imdf/ipig/hyps/tumr
|
proc, drug (L3/4)
|
|
|
|