MMP2

MMP2

Identifiers Symbols MMP2; CLG4; CLG4A; MMP-II; MONA; TBE-1 External IDs OMIM: 120360 MGI: 97009 HomoloGene: 3329 ChEMBL: 333 GeneCards: MMP2 Gene EC number 3.4.24.24

Gene Ontology
Molecular function	• metalloendopeptidase activity • serine-type endopeptidase activity • protein binding • zinc ion binding • metal ion binding
Cellular component	• extracellular region • proteinaceous extracellular matrix • extracellular space • nucleus • mitochondrion • plasma membrane • sarcomere
Biological process	• angiogenesis • response to hypoxia • blood vessel maturation • intramembranous ossification • proteolysis • embryo implantation • extracellular matrix disassembly • extracellular matrix organization • collagen catabolic process • face morphogenesis • bone trabecula formation • cellular response to amino acid stimulus
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 4313 17390 Ensembl ENSG00000087245 ENSMUSG00000031740 UniProt P08253 P33434 RefSeq (mRNA) NM_001127891 NM_008610 RefSeq (protein) NP_001121363 NP_032636 Location (UCSC) Chr 16:
55.42 – 55.54 Mb Chr 8:
92.83 – 92.85 Mb PubMed search

72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.