Ballpark Firsts
| Statistic | Person(s) | Date |
| First Ceremonial First Pitch | Kenneth Lay | April 7, 2000 |
| First Hit | Doug Glanville (Philadelphia Phillies), single to right | April 7, 2000 |
| First Astros Hit | Craig Biggio, single to center | April 7, 2000 |
| First Double | Rico Brogna (Philadelphia Phillies) | April 7, 2000 |
| First Astros Double | Craig Biggio | April 8, 2000 |
| First Triple | Tim Bogar | April 8, 2000 |
| First Home Run | Scott Rolen (Philadelphia Phillies) | April 7, 2000 |
| First Astros Home Run | Richard Hidalgo | April 7, 2000 |
| First Grand Slam | Thomas Howard (St. Louis Cardinals) | April 11, 2000 |
| First Astros Grand Slam | Ken Caminiti | May 9, 2000 |
| First Cycle | Luis Gonzalez (Arizona Diamondbacks) | July 5, 2000 |
| First Astros Cycle | Jeff Bagwell | July 18, 2001 |
| First Winning Pitcher | Randy Wolf (Philadelphia Phillies) | April 7, 2000 |
| First Astros Winning Pitcher | Mike Maddux | April 8, 2000 |
| First Save | Wayne Gomes (Philadelphia Phillies) | April 7, 2000 |
| First Astros Save | Billy Wagner | April 8, 2000 |
| First Shutout | Minnesota Twins 2-0 | June 7, 2000 |
| First Astros Shutout | 3-0 over the Chicago Cubs | July 22, 2001 |
| First postseason game | 7 - 4 loss to the Atlanta Braves | October 9, 2001 |
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