Minichromosome - Role in Genetic Engineering

Role in Genetic Engineering

Unlike traditional methods of genetic engineering, minichromosomes can be used to transfer and express multiple sets of genes onto one engineered chromosome package Traditional methods which involve the insertion of novel genes into existing sequences may result in the disruption of endogenous genes and thus negatively affect the host cell. Additionally, with traditional gene insertion methods, scientists have had less ability to control where the newly inserted genes are located on the host cell chromosomes which makes it difficult to predict inheritance of multiple genes from generation to generation. Minichromosome technology allows for the stacking of genes side-by-side on the same chromosome thus reducing likelihood of segregation of novel traits.

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