Michio can refer to:
- Michio Kaku, a Japanese American theoretical physicist
- Michio Mamiya, a Japanese pianist, harpsichordist, and conductor of baroque and classical music
- Michio Miyagi, a Japanese musician famous for his koto playing
- Michio Morishima, a Japanese economist and emeritus professor of LSE
- Michio Yuki, the antagonist of manga series, MW
- Michio, the main character in the Michio-Kozue Japanese folktale
- Michio, the Japanese word, meaning 'person with the strength of three thousand'