Major Highways
- Interstate 75 - Runs north to south more or less along the valley and through downtown Dayton.
- Interstate 70 - Traverses the valley from east to west.
- Interstate 71 - Runs north to south along the eastern half of the Miami Valley.
- Interstate 675 - Bypasses Dayton from I-75 south of the city to I-70 east of it.
- U.S. Route 35 - Runs east to west through the Dayton metro area.
- U.S. Route 68 - Runs north to south through fertile farmlands in the eastern Miami Valley.
- Ohio State Route 129 - Connects Hamilton to I-75.
- Ohio State Route 49 - Forms a bypass west of Dayton and continues north into Darke County.
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