A Mendelian trait is one that is controlled by a single locus and shows a simple Mendelian inheritance pattern. In such cases, a mutation in a single gene can cause a disease that is inherited according to Mendel's laws. Examples include sickle-cell anemia, Tay-Sachs disease, cystic fibrosis and xeroderma pigmentosa. A disease controlled by a single gene contrasts with a multi-factorial disease, like arthritis, which is affected by several loci (and the environment) as well as those diseases inherited in a non-Mendelian fashion. The Mendelian Inheritance in Man database is a catalog of, among other things, genes in which Mendelian traits cause disease.
Read more about this topic: Mendelian Inheritance
Famous quotes containing the word trait:
“This is ... a trait no other nation seems to possess in quite the same degree that we do—namely, a feeling of almost childish injury and resentment unless the world as a whole recognizes how innocent we are of anything but the most generous and harmless intentions.”
—Eleanor Roosevelt (1884–1962)