Melas can be
- Pavlos Melas (1870–1904), an officer of the Greek army.
- Panagiotis Melas, Greek politician and member of the Greek Parliament.
- Melas, Kastoria, the village where Pavlos Melas died, part of the municipality Kastoria, Greece
- Pavlos Melas (municipality), a municipality in the urban area of Thessaloniki, Greece
- Michael von Melas, an Austrian field marshal during the Napoleonic Wars
- MELAS - Mitochondrial Encephalomyopathy, Lactic Acidosis, Stroke-like episodes.
- Melas (mythology), name of eight different characters in Greek mythology