Future and Current Research
More in-depth investigations into the biological role of EVI1 in development are required, as well as further characterizing the mode(s) of activation of this gene in cancer cells. Once the knowledge base is more developed, it is likely that screening for specific EVI1 antagonists or inhibitors will become more feasible, and improve the current treatment regimen for patients.
Areas where retroviral integration into the human genome is favored such as EVI1 have very important implications for the development of gene therapy. It was initially thought that delivery of genetic material through a non-replicating virus vector would pose no significant risk, as the likelihood of a random incorporation near a proto-oncogene was minimal. However, it has now been shown that sites such as EVI1 are "highly over-represented" when it comes to vector insertions. With gene therapy gradually becoming a more popular idea, large studies must be conducted to understand the dynamic of why vector integration occurs where it does, and what factors influence the 'non-randomness' of the process.
Read more about this topic: MECOM
Famous quotes containing the words future, current and/or research:
“In any future great national trial, compared with the men of this, we shall have as weak, and as strong; as silly and as wise; as bad and good.”
—Abraham Lincoln (1809–1865)
“I perceived that to express those impressions, to write that essential book, which is the only true one, a great writer does not, in the current meaning of the word, invent it, but, since it exists already in each one of us, interprets it. The duty and the task of a writer are those of an interpreter.”
—Marcel Proust (1871–1922)
“The working woman may be quick to see any problems with children as her fault because she isn’t as available to them. However, the fact that she is employed is rarely central to the conflict. And overall, studies show, being employed doesn’t have negative effects on children; carefully done research consistently makes this clear.”
—Grace Baruch (20th century)