MDC usually refers to:
- Movement for Democratic Change – Tsvangirai (MDC-T), a Zimbabwean political party
- Movement for Democratic Change (pre-2005), a former Zimbabwean political party that split in 2005 into the MDC-T and MDC-M
- Movement for Democratic Change – Mutambara (MDC-M), a Zimbabwean political party, the smaller of the parties that came out of the 2005 split.
- MDC (band) (Millions of Dead Cops), an American rock band
Other meanings include:
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