Criticism
McDonald criteria have been shown to have a low sensitivity and specificity (with respect to the presence of lesions) in Asiatic populations. They present instead a good behaviour (respect CIS to CDMS conversion) when evaluated in non-selected populations.
Some other authors consider McDonald criteria as an attempt for a clinical definition and propose a pathological definition instead. According to Hans Lassmann, the pathological definition should be preferred because the clinical definitions have problems with differential diagnosis. Besides, subclinical MS cases would not be accepted as MS cases by this criteria
Finally McDonald also states "objective evidence of dissemination in time and space of lesions typical of MS is essential in making a secure diagnosis, as is the exclusion of other, better explanations for the clinical features". Therefore, when used as a definition, the McDonald criteria is defining MS just by exclusion of other diseases.
Read more about this topic: McDonald Criteria
Famous quotes containing the word criticism:
“Unless criticism refuses to take itself quite so seriously or at least to permit its readers not to, it will inevitably continue to reflect the finicky canons of the genteel tradition and the depressing pieties of the Culture Religion of Modernism.”
—Leslie Fiedler (b. 1917)
“When you overpay small people you frighten them. They know that their merits or activities entitle them to no such sums as they are receiving. As a result their boss soars out of economic into magic significance. He becomes a source of blessings rather than wages. Criticism is sacrilege, doubt is heresy.”
—Ben Hecht (1893–1964)
“The greater the decrease in the social significance of an art form, the sharper the distinction between criticism and enjoyment by the public. The conventional is uncritically enjoyed, and the truly new is criticized with aversion.”
—Walter Benjamin (1892–1940)