Compounds From Marine Sources in Clinical Level
| Clinical Status | Compound Name | Trademark | Marine Organismα | Chemical Class | Molecular Target | Clinical Trialsβ | Disease Area |
|---|---|---|---|---|---|---|---|
| FDA-Approved | Cytarabine (Ara-C) | Cytosar-U® | Sponge | Nucleoside | DNA Polymerase | >50/711 | Cancer |
| Vidarabine (Ara-A) | Vira-A® | Sponge | Nucleoside | Viral DNA Polymerase | 0 | Antiviral | |
| Ziconotide | Prialt® | Cone Snail | Peptide | N-Type Ca2+ Channel | 2/5 | Analgesic | |
| Eribulin Mesylate (E7389) | Halaven® | Sponge | Macrolide | Microtubules | 19/27 | Cancer | |
| Omega-3-Fatty Acid Ethyl Esters | Lovaza® | Fish | Omega-3 Fatty Acids | Triglyceride-Synthesizing Enzymes | 45/94 | Hypertriglyceridemia | |
| Trabectedin (ET-743) EU Approved only | Yondelis® | Tunicate | Alkaloid | Minor Groove of DNA | 17/34 | Cancer | |
| Phase III | Brentuximab Vedotin (SGN-35) | Adcetris® | Mollusk | Antibody-Drug Conjugate (MM Auristatin E) | CD30 and Microtubules | 9/19 | Cancer |
| Plitidepsin | Aplidin® | Tunicate | Depsipeptide | Rac1 and JNK Activation | 1/7 | Cancer | |
| Phase II | DMXBA (GTS-21) | N/A | Worm | Alkaloid | Alpha-7 Nicotinic Acetylcholine Receptor | 0/3 | Congnition, Schizophrenia |
| Plinabulin (NPI 2358) | N/A | Fungus | Diketopiperazine | Microtubules and JNK Stress Protein | 1/2 | Cancer | |
| Elisidepsin | Irvalec® | Mollusk | Depsipeptide | Plasma Membrane Fluidity | 1/2 | Cancer | |
| PM00104 | Zalypsis® | Nudibranch | Alkaloid | DNA-Binding | 2/3 | Cancer | |
| Glembatumumab Vedotin (CDX-011) | N/A | Mollusk | Antibody Drug Conjugate (MM Auristatin E) | Glycoprotein NMB and Microtubules | 1/3 | Cancer | |
| Phase I | Marizomib (Salinosporamide A) | N/A | Bacterium | Beta-Lactone-Gamma Lactam | 20S Proteasome | 4/4 | Cancer |
| PM01183 | N/A | Tunicate | Alkaloid | Minor Groove of DNA | N/A | Cancer | |
| SGN-75 | N/A | Mollusk | Antibody Drug Conjugate (MM Auristatin F) | CD70 and Microtubules | 2/2 | Cancer | |
| ASG-5ME | N/A | Mollusk | Antibody Drug Conjugate (MM auristatin E) | ASG-5 and Microtubules | 2/2 | Cancer | |
| Hemiasterlin (E7974) | N/A | Sponge | Tripeptide | Microtubules | 0/3 | Cancer | |
| Bryostatin 1 | N/A | Bryozoa | Polyketide | Protein Kinase C | 0/38 | Cancer, Alzheimers | |
| Pseudopterosins | N/A | Soft Coral | Diterpene Glycoside | Eicosanoid Metabolism | N/A | Wound Healing |
αIncludes natural products or natural product derivatives or analogues; βNumber of active trials/number of total trials from http://www.clinicaltrials.gov/ as of July 2011
Read more about this topic: Marine Pharmacognosy
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