Marine Pharmacognosy

Marine Pharmacognosy

For many years, traditional Western pharmacognosy focused on the investigation and identification of medically important plants and animals in the terrestrial environment, although many marine organisms were used in Traditional Chinese Medicine. With the development of the open-circuit self-contained underwater breathing apparatus or SCUBA in the 1940s, some chemists turned to more pioneering work looking for new medicines in the marine environment. In the United States, the road has been long for the first FDA approval of a drug directly from the sea, but in 2004, the approval of ziconotide isolated from a marine cone snail has paved the way for other marine-derived compounds moving through clinical trials.

With 79% of the earth’s surface covered by water, research into the chemistry of marine organisms is relatively unexplored and represents a vast resource for new medicines to combat major diseases such as cancer, AIDS or malaria. Research typically focuses on sessile organisms or slow moving animals because of their inherent need for chemical defenses. Standard research involves an extraction of the organism in a suitable solvent followed by either an assay of this crude extract for a particular disease target or a rationally guided isolation of new chemical compounds using standard chromatography techniques.