Margolin may refer to:
- MCM pistol, a Russian sport pistol developed by Mikhail Margolin
Margolin is a surname, and may refer to:
- Arnold Margolin, American television producer, screen writer, and director
- Bob Margolin, American guitarist
- Bruce Margolin, American criminal defense attorney
- Janet Margolin, American actress
- Julius Margolin, Jewish writer and political activist
- Malcolm Margolin, American independent publisher, author
- Phillip Margolin, American writer and lawyer
- Stuart Margolin, American film and television actor
- Veniamin Margolin, Russian trumpeter