Efficacy and Side Effects
Kv1.3 is already linked with proliferation of lymphocytes, vascular smooth cells, oligodendrocytes and cancer cells. Recent studies have shown that there is therapeutical potential for Kv1.3-blockers such as Margatoxin.
In a minipig treatment a study with margatoxin has been conducted. An eight-day treatment led to a prolonged immune suppression that lasted three to four weeks after termination of dosing. Thymic atrophy (reduced thymus) was observed. Especially the cells in the cortical region had decreased in number
Read more about this topic: Margatoxin
Famous quotes containing the words efficacy and, efficacy, side and/or effects:
“For books are not absolutely dead things, but do contain a potency of life in them to be as active as that soul was whose progeny they are; nay, they do preserve as in a vial the purest efficacy and extraction of that living intellect that bred them. I know they are as lively, and as vigorously productive, as those fabulous dragons teeth; and being sown up and down, may chance to spring up armed men.”
—John Milton (16081674)
“If there is a case for mental events and mental states, it must be that the positing of them, like the positing of molecules, has some indirect systematic efficacy in the development of theory.”
—Willard Van Orman Quine (b. 1908)
“If I were tickled by the rub of love,
A rooking girl who stole me for her side ...”
—Dylan Thomas (19141953)
“The hippie is the scion of surplus value. The dropout can only claim sanctity in a society which offers something to be dropped out ofcareer, ambition, conspicuous consumption. The effects of hippie sanctimony can only be felt in the context of others who plunder his lifestyle for what they find good or profitable, a process known as rip-off by the hippie, who will not see how savagely he has pillaged intricate and demanding civilizations for his own parodic lifestyle.”
—Germaine Greer (b. 1939)