Mangano is a surname. Notable people with the surname include:
- Anthony Mangano, American actor
- Ed Mangano, Nassau County Executive, (2010–Present)
- Joy Mangano, American inventor
- Lawrence Mangano, American mobster
- Silvana Mangano (1930-1989), Italian actress
- Venero Mangano, American mafioso
- Vincent Mangano (1888 – 1951), mafioso
- Vittorio Mangano (1940 – 2000), member of Cosa Nostra