Lupino or Luppino is a surname of Italian origin, meaning little wolf. The name refers to:
- The Lupino family of British and American actors:
- Ida Lupino (1918–1995), Anglo-American film actress and director
- Lupino Lane (Henry William George Lupino) (1892–1959), British actor
- Richard Lupino (1929–2005), American actor
- Stanley Lupino (1893–1942), English actor, dancer, and author; father of Ida Lupino
- Wallace Lupino (1898–1961), British film actor
- Nathalie Lupino (born 1963), French judoka
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