Local Anesthetic - Naturally Derived Local Anesthetics

Naturally Derived Local Anesthetics

  • Saxitoxin
  • Neosaxitoxin
  • Tetrodotoxin
  • Menthol
  • Eugenol

Naturally occurring local anesthetics not derived from cocaine are usually neurotoxins, and have the suffix -toxin in their names. Unlike cocaine produced local anesthetics which are intracellular in effect, saxitoxin, neosaxitoxin & tetrodotoxin bind to the extracellular side of sodium channels.

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