Loading Dose - Calculating The Loading Dose

Calculating The Loading Dose

Four variables are used to calculate the loading dose:

Cp = desired peak concentration of drug
Vd = volume of distribution of drug in body
F = bioavailability
S = salt fraction

The required loading dose may then be calculated as

For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.

Read more about this topic:  Loading Dose

Famous quotes containing the words calculating the, calculating, loading and/or dose:

    [The] elderly and timid single gentleman in Paris ... never drove down the Champs Elysees without expecting an accident, and commonly witnessing one; or found himself in the neighborhood of an official without calculating the chances of a bomb. So long as the rates of progress held good, these bombs would double in force and number every ten years.
    Henry Brooks Adams (1838–1918)

    I know that the right kind of leader for the Labour Party is a kind of desiccated calculating machine.
    Aneurin Bevan (1897–1960)

    Nitrates and phosphates for ammunition. The seeds of war. They’re loading a full cargo of death. And when that ship takes it home, the world will die a little more.
    Earl Felton, and Richard Fleischer. Captain Nemo (James Mason)

    Whipping and abuse are like laudanum: you have to double the dose as the sensibilities decline.
    Harriet Beecher Stowe (1811–1896)