S
- The San Pedro Beach Bums (San Pedro)
- Sanford and Son (Watts)
- Saved By The Bell (Fictional town of Palisades)
- The Secret Life of the American Teenager
- Sex, Love & Secrets (Silver Lake)
- Shark
- The Shield
- Six Feet Under
- Sleeper Cell
- Sliders (although initially, the show was set in San Francisco, most episodes from the third to fifth season took place in Los Angeles)
- Sonny With A Chance
- So Little Time (Malibu)
- South Central
- South of Nowhere
- Southland
- Sparks (Compton)
- Starsky and Hutch
- The Starter Wife
- Studio 60 on the Sunset Strip
- Summerland
- S.W.A.T.
- Sweet Valley High (Fictional Suburb of Sweet Valley)
- Switch
Read more about this topic: List Of Television Shows Set In Los Angeles