1950s
- Ray Abruzzo (born 1954) television actor (The Sopranos)
- Sharon Angela (born 1958) television actress (The Sopranos)
- Michael Badalucco (born 1954) film actor (O Brother, Where Art Thou?)
- Danny Bonaduce (born 1959) Italian father - television actor (The Partridge Family)
- Elizabeth Bracco (born 1959) Italian father and English mother- television actress (The Sopranos)
- Lorraine Bracco (born 1954) Italian father and English mother- Academy Award-nominated actress (The Sopranos, Goodfellas)
- Steve Buscemi (born 1957) Italian father and part Irish mother- actor (Fargo, Reservoir Dogs)
- Joseph Cali (born 1950) film actor (Saturday Night Fever)
- Carl Capotorto (born 1959) television actor (The Sopranos)
- David Caruso (born 1956) Italian father and Irish mother- film/television actor (CSI: Miami)
- Vincent Curatola (born 1953) son of Sicilian parents- television actor (The Sopranos)
- Beverly D'Angelo (born 1951) 25% Italian blood- film actress (Vacation)
- Tony Danza (born 1951) actor/talk show host (Who's The Boss, Family Law)
- Robert Davi (born 1951) film actor (The Goonies)
- Michael DeLorenzo (born 1959) Italian father and Puerto Rican mother- television/film actor (New York Undercover)
- Vincent D'Onofrio (born 1959) son of Sicilian parents – film/television actor and director (Full Metal Jacket, Law and Order: Criminal Intent)
- Giancarlo Esposito (born 1958) Italian father and African-American mother- film actor
- Lou Ferrigno (born 1951) bodybuilder and actor (The Hulk)
- Robert Funaro (born 1959) television actor (The Sopranos)
- Joseph Gannascoli (born 1959) television actor (The Sopranos)
- Dan Grimaldi (born 1950) television actor (The Sopranos)
- Robert Hegyes (1951–2012) television actor ("Welcome Back, Kotter") Italian-American mother, Hungarian-American father
- Hulk Hogan (Terry Gino Bollea) (born 1953) 50% Italian wrestler
- Anjelica Huston (born 1951) Italian-American mother and part Irish father- film actress (Prizzi's Honor)
- Renée Jones (born 1958) Italian mother and African-American father- soap opera actress (Days of our Lives)
- Cyndi Lauper (born 1953) Italian mother and Swiss and German father- singer and actress- (Girls Just Wanna Have Fun)
- Jay Leno (born 1950) Italian-American father and Scottish mother- comedian, former actor, known as host of The Tonight Show
- Madonna (Ciccone) (born 1958) 50% Italian, 50% French Canadian – singer, songwriter, dancer, actress, entertainer (Dick Tracy)
- Ed Marinaro (born 1950) actor and former football player
- Chazz Palminteri (born 1952) film actor (A Bronx Tale)
- Joe Pantoliano (born 1951) film/television actor (The Sopranos)
- Joe Penny (born 1956) Italian mother and English father- television actor
- Joe Piscopo (born 1951) actor and comedian (Saturday Night Live)
- Jon Polito (born 1950) Italian father and Anglo-American mother- actor (The Honeymooners)
- Ray Romano (born 1957) actor and comedian (Everybody Loves Raymond)
- Isabella Rossellini (born 1952) Italian father and Swedish mother - actress, filmmaker, author, philanthropist, model
- James Russo (born 1953) film/television actor (Donnie Brasco)
- Rene Russo (born 1954) Italian father and Italian maternal grandfather, film actress/model (Lethal Weapon 3, The Thomas Crown Affair)
- Randy Savage (Randall Mario Poffo) (1952–2011) Italian father and Jewish mother- wrestler and actor
- Jack Scalia (born 1950) television actor (The Genius Club)
- Steve Schirripa (born 1957) television actor and writer (The Sopranos)
- Connie Sellecca (Sellecchia) (born 1955) actress
- Gary Sinise (born 1955) 25% Italian blood- actor (CSI: NY)
- Rocco Sisto (born 1953) Italian born actor (The Sopranos)
- Frank Sivero (LoGiudice) (born 1952) Italian born actor (Goodfellas)
- Joseph Siravo (born 1958) film/television actor (The Sopranos)
- John Travolta (born 1954) Italian-American father and Irish-American mother- Academy Award-nominated actor, singer, dancer (Grease, Saturday Night Fever)
- John Turturro (born 1957) actor, cousin of Aida Turturro (The Good Shepherd, The Bronx Is Burning)
- Steven Van Zandt (Lento) (born 1950) musician, songwriter, arranger, record producer, actor, and disc jockey (The Sopranos)
- Vinny Vella (born 1950) actor and part time comedian
- Diane Venora (born 1952) actress (Italian-American father)
- Chuck Zito (born 1957) member of the New York chapter of the Hells Angels, amateur boxer, martial artist, celebrity bodyguard, stuntman and actor
- Pia Zadora (born 1954) Broadway actress Italian father: Polish mother
Read more about this topic: List Of Italian American Actors