1940s
- Marc Alaimo (born 1942) television/film actor (Star Trek: Deep Space Nine)
- Armand Assante (born 1949) Italian father and Irish mother- film/television actor (Mambo Kings)
- Joy Behar (Josephina Ochiuto) (born 1943) actress, comedian, co-host of The View
- Tony Darrow (Borgese) (born 1946) film/television actor
- Robert De Niro (born 1943) 25% Italian ancestry- two time Academy Award-winning American film actor, director, producer and founder of the Tribeca Film Festival (Goodfellas)
- Danny DeVito (born 1944) actor, director, Oscar nominated producer (Matilda) *
- Micky Dolenz (born 1945) Television actor/Musician (The Monkees) Father Italian, an actor.
- Dennis Farina (born 1944) son of Sicilian parents- film/television actor (Get Shorty)
- Annette Funicello (born 1942) actress, was Walt Disney's most popular Mouseketeer
- Bruno Kirby (Quidaciolu) (1949–2006) son of Sicilian parents- film actor (The Godfather II)
- Susan Lucci (born 1948) 50% Italian and part Swedish- Daytime Emmy Award winning actress, who has been called "Daytime's Leading Lady" and "The Queen of Daytime"
- Patti LuPone (born 1949) singer and actress
- Joe Mantegna (born 1947) film/television actor (The Godfather III)
- Penny Marshall (Marsciarelli) (born 1942) Italian-American father and part Scottish mother—actress, producer and director, sister of Garry Marshall
- Patty McCormack, born Patricia Ellen Russo (born 1945), Italian father and Irish mother – Actress (The Bad Seed)
- Liza Minnelli (born 1946) part Italian father and part Irish-American mother- singer and actress
- Arthur Nascarella (born 1942) son of Sicilian parents- film/ television actor (The Sopranos)
- Don Novello (born 1943) Italian father and Irish mother- film/television actor and comedian (Saturday Night Live)
- Al Pacino (born 1940) son of Sicilian parents- Academy Award-winning film actor (The Godfather)
- Vincent Pastore (born 1946) son of Sicilian parents- film/television actor, often cast as a mobster (The Sopranos)
- Joe Pesci (born 1943) Academy Award-winning actor, comedian and singer who is often typecast as a violent mobster or funnyman (Goodfellas, Casino)
- Frank Pellegrino (born 1942) television actor
- Bernadette Peters (Lazzara) (born 1948) actress and singer
- Ann Prentiss (Ragusa) (born 1941) film/television actress- sister of Paula Prentiss
- Michael Richards (born 1949) Italian-American mother and English-American father- television actor (Seinfeld)
- Tommy Rettig (1941–1996) Italian-American mother and Jewish Father - television actor (Lassie)
- Susan Sarandon (born 1946) Italian-American mother and American father- Academy Award-winning film actress (Thelma and Louise)
- Vincent Schiavelli (1948–2005) film actor
- Talia Shire (born 1946) film actress, sister of Francis Ford Coppola (Rocky)
- Nancy Sinatra (born 1940) singer and actress, daughter of Frank Sinatra
- Bruce Springsteen (born 1949) 50% Italian, 25% Irish and part Dutch- singer and actor
- Sylvester Stallone (born 1946) - film actor, director, producer, and screenwriter (Rocky)
- Tony Sirico (born 1942) son of Sicilian parents- film/television actor (The Sopranos)
- Victoria Vetri (born 1944) model and actress
- Burt Young (DeLuise) (born 1940) film actor (Rocky)
- Adrienne La Russa (born 1948) actress (Days of our lives)
- Dan Lauria (born 1947) TV and film actor
Read more about this topic: List Of Italian American Actors