Lilo or LILO may refer to:
- Lilo (actress) (born 1925), a French actress and singer, star of Can-Can (musical)
- LILO (boot loader), Linux Loader, a piece of low-level software
- Lilo (footballer) (born 1983), Brazilian footballer Murilo Rufino Barbosa
- Lilo Pelekai, a character in the 2002 Disney film Lilo & Stitch
- Didi Lilo, Georgia, a village outside Tblisi, site of a nuclear accident
- Left-in/left-out, a roadway intersection
- lilo, UK term for an air mattress, from the trademark Li-Lo
- Lilo, nickname of mobster Carmine Galante
- LiLo, nickname of actress Lindsay Lohan