LGB may refer to:
- Long Beach Airport in California
- Laser-guided bomb
- Lateral geniculate body in human brain, a.k.a. lateral geniculate nucleus
- LGB (trains), brand in model railroading
- "LGB", term for lesbian, gay, and bisexual people, sharing history with term "LGBT"
- Lou Gramm Band, led by Lou Gramm
- Little grey bird, a.k.a. Little brown job
- Little Golden Books for children
- La Grande Boissière, largest campus: International School of Geneva
- Lectures on Government and Binding: The Pisa Lectures, a book by American linguist Noam Chomsky