Leeke is a surname, held by the following notable people:
- Edward Tucker Leeke (1842–1925) – British clergyman and scholar, Canon and sub-dean of Lincoln Cathedral.
- George Leeke, MP for Mid-Londonderry 1929–1939
- Gerald Llewellyn Leeke, OBE and CEO of the Leekes Group of Companies.
- Henry Leeke (athlete) (d. 1922), notable Cambridge athlete
- Henry Alan Leeke (1879–1915), British track and field athlete and Olympian, son of Henry Leeke
- Sir Henry John Leeke (1794–1870) – Royal Navy Admiral
- John Cox Leeke (1843–1919) – Bishop of Woolwich
- Laurence Leeke (d. 1357) – prior of Norwich
- Samuel Leeke, magistrate and Deputy Lieutenant for the Hampshire
- Revd William Leeke (1797–1879) – British army officer who wrote memoirs of Waterloo
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