Lackawanna (from a Lenni Lenape word meaning "stream that forks") relates to several places in the United States:
- Lackawanna, New York, a city in Erie County, New York
- Lackawanna Coal Mine, a former mine turned museum in Scranton, Pennsylvania
- Lackawanna College, a college in Scranton, Pennsylvania
- Lackawanna County, Pennsylvania, a county in northeast Pennsylvania, of which the county seat is Scranton
- Lackawanna River, a tributary of the Susquehanna River in northeastern Pennsylvania
- Lackawanna State Forest, in northeastern Pennsylvania
- Lackawanna State Park, in northeastern Pennsylvania
- Lackawanna Steel Company, a former steel company that started in Scranton then moved to western New York
- Lake Lackawanna, Byram Twp., Sussex County, NJ, a man made lake (circa 1911) and golf course owned by the Lake Lackawanna Investment Company
An extant railroad company in the United States:
- Delaware–Lackawanna Railroad
Several former railroad companies in the United States:
- Erie Lackawanna Railroad
- Delaware, Lackawanna and Western Railroad, also known as the Lackawanna Railroad
- Lackawanna and Bloomsburg Railroad
- Lackawanna and Western Railroad
- Lackawanna and Wyoming Valley Railroad
The arts:
- The Lackawanna Valley, a circa 1855 painting by George Inness
- Lackawanna Blues, a 2001 Ruben Santiago-Hudson play that became a 2005 television movie