La Gioconda (/ˌdʒiːəˈkɒndə/; "the joyful one") may refer to:
- Mona Lisa or La Gioconda, a painting by Leonardo da Vinci
- Lisa del Giocondo, the model depicted in da Vinci's painting
- La Gioconda (opera), an opera by Amilcare Ponchielli
- La Gioconda (1899), tragedy by Gabriele d'Annunzio
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